Ferring statement on subsidised pricing of heat-stable carbetocin for the prevention of postpartum haemorrhage in low- and lower-middle income countries

Saint-Prex, Switzerland – 18 March 2019 –

Ferring welcomes the recent update to the World Health Organization (WHO) recommendations relating to uterotonics for the prevention of postpartum haemorrhage (PPH), with specific mention of carbetocin.¹

Every year, 14 million women are affected by PPH.² PPH is the leading direct cause of maternal death worldwide, causing approximately 70,000 deaths per year, 99% of which occur in low- and lower-middle income countries.^1,4

Ferring is now seeking registrations for the heat-stable formulation of carbetocin* for the prevention of PPH following all births and is committed to making heat-stable carbetocin available to the public sector in low- and lower-middle income countries.⁴ as a priority following appropriate regulatory approval.

Once approved, the heat-stable formulation of carbetocin will be made available at an affordable and sustainable price in public-sector healthcare facilities in low- and lower-middle income countries.⁴ This price is a subsidised price of $0.31 +/- 10% per ampoule of 100 µg heat-stable carbetocin. This price is Ex Works, which is the price at the point of leaving the manufacturing site and does not include the logistical costs of getting the medicine to healthcare providers. This is comparable to the current United Nations Population Fund price for oxytocin of $0.33 per unit (10 I.U.).⁵

*The availability of investigational heat-stable carbetocin is subject to regulatory review and approval in relevant countries.

About Ferring Pharmaceuticals

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women’s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

Learn more at www.ferring.com, or connect with us on LinkedIn, Instagram, Facebook, Twitter and YouTube.

References

1. World Health Organization. WHO recommendations: Uterotonics for the prevention of postpartum haemorrhage. Published 2018. Available at: http://apps.who.int/iris/bitstream/handle/10665/277276/9789241550420-eng.pdf?ua=1 Last accessed: March 2019.
2. World Health Organization. Priority diseases and reasons for inclusion. Postpartum haemorrhage. Available at: https://www.who.int/medicines/areas/priority_medicines/Ch6_16PPH.pdf Last accessed: March 2019.
3. Say L, et al. Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health. 2014; 2(6):e323-33. Available at: https://www.thelancet.com/pdfs/journals/langlo/PIIS2214-109X(14)70227-X.pdf Last accessed: March 2019.
4. World Bank. World Bank Country and Lending Groups. Published 2019. Available at: https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groupsLast accessed: March 2019
5. UNFPA Product Catalog, accessed 25 July 2019 https://www.unfpaprocurement.org/products?id=OXYTOCIN_10IU/ML

Ferring, Rebiotix and Karolinska Institutet extend collaboration to research next generation of microbiome treatments

• Collaboration brings together expertise from Ferring, Rebiotix and Karolinska Institutet to unlock the potential of the human microbiome

• The collaboration will investigate the role of the microbiome in reproductive medicine and women’s health and gastroenterology through 10 clinical studies involving approximately 9,000 people

• The data collected will support future research and development in areas of high unmet need, including recurrent pregnancy loss, preterm birth and inflammatory bowel disease

Saint-Prex, Switzerland – 22 January, 2019 –

Ferring Pharmaceuticals and Karolinska Institutet announced today a five-year extension of their collaboration to explore the potential of the human microbiome in reproductive medicine and women’s health and gastroenterology. The collaboration brings together specialist expertise from Karolinska Institutet in early stage research, Rebiotix Inc. (acquired by Ferring in 2018), a late-stage clinical microbiome company, and Ferring’s therapeutic area and commercialisation capabilities.

The extension includes six reproductive health clinical studies of approximately 6,000 women and babies and four gastroenterology studies of approximately 3,000 adults and children, to further investigate the role of the microbiome in areas of high unmet need including recurrent pregnancy loss, preterm birth and inflammatory bowel disease.

“The extension of this partnership presents an exciting research opportunity, bringing together unique capabilities of Ferring, Karolinska Institutet and Rebiotix across the clinical development continuum in the mircrobiome space,” said Lee Jones, Founder, President and Chief Executive Officer, Rebiotix, Inc. “This, together with Ferring’s significant experience in reproductive medicine and gastroenterology, offers the potential to drive future research and development for the next generation of microbiome treatments needed to help more people build healthy families and live better lives.”

Up to 5% of couples face the heartache of recurrent pregnancy loss¹ and around 15 million babies are born preterm every year around the world, with approximately 1 million children dying each year due to related complications.² Over 10 million people worldwide live with the pain and discomfort of inflammatory bowel disease.³ With reproductive health and inflammatory bowel concerns on the rise,^2,4 there is a need to increase understanding of their causes and develop new solutions.

“This innovative public-private partnership demonstrates our ongoing, shared commitment to investigating the human microbiome,” said Lars Engstrand, Professor at Karolinska Institutet and Director of the Center for Translational Microbiome Research. “It will support the expansion of Karolinska Institutet’s foundation of robust biological data and drive our understanding of the microbiome’s impact on important reproductive and gut health challenges.”

– ENDS –

About Ferring Pharmaceuticals

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women’s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

Learn more at www.ferring.com, or connect with us on Twitter, Facebook, Instagram, LinkedIn and YouTube.

About Rebiotix Inc.

Rebiotix Inc., part of the Ferring Pharmaceuticals Group, is a late-stage clinical microbiome company focused on harnessing the power of the human microbiome to revolutionise the treatment of challenging diseases. Rebiotix possesses a deep and diverse clinical pipeline targeting several other disease states with drug products built on its pioneering Microbiota Restoration Therapy™ (MRT™) drug platform. The MRT platform is a standardised, stabilised drug technology that is designed to rehabilitate the human microbiome by delivering a broad consortium of live microbes into a patient’s intestinal tract via a ready-to-use and easy-to-administer format.

For more information on Rebiotix and its pipeline of human microbiome-directed therapies, visit www.rebiotix.com.

About Karolinska Institutet

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

For more information please visit www.ki.se/en.

For more information, please contact

Lindsey Rodger
Senior Manager, Corporate Communications
+41 58 451 40 23 (direct)
+41 79 191 04 86 (mobile)
lindsey.rodger@ferring.com

References

1. Hachem HE, Crepaux V, May-Panloup P, et al. Recurrent pregnancy loss: current perspectives. International Journal of Womens Health. 2017; 9: 331–345.
2. WHO. Preterm birth. 2018. Available at: https://www.who.int/news-room/fact-sheets/detail/preterm-birth [Accessed: January 2019].
3. Crohn’s & Colitis Foundation. World IBD Day: Beyond Borders May 19, 2018. Available at: http://www.crohnscolitisfoundation.org/WorldIBDDay/ [Accessed: January 2019].
4. Kaplan G. The global burden of IBD: from 2015 to 2025. Nature Reviews Gastroenterology & Hepatology. 2015; 12:720–727

Ferring announces recipients of 2018-19 Innovation Grants

• Ferring Pharmaceuticals today announced the recipients of the 2018-19 Ferring Innovation Grants Program

• This year’s program is focused on reproductive medicine and women’s health, gastroenterology and hepatology, urology, and biomarker discovery

Saint-Prex, Switzerland – 3 December, 2018 –

Ferring Pharmaceuticals today announced the recipients of the 2018-19 Ferring Innovation Grants Program, an annual initiative of the Ferring Research Institute (FRI) based in San Diego. This year the program focused on reproductive medicine and women’s health, gastroenterology and hepatology, urology, and biomarker discovery. The grant recipients, together with the titles of their projects, are:

• Fiona Cousins, PhD – Hudson Institute of Medical Research, Monash University
  New treatment of endometriosis in a preclinical model
• Laurent Derré, PhD – University Hospital of Lausanne (CHUV)
  Immunotherapeutic strategies targeting ILC2 and MDSCs to treat bladder cancer
• Marta Dueñas, PhD – Fundación para la Investigación Hospital 12 de Octubre
  Evaluation of miRNAs and miRNA derived peptides (miPEPs) in liquid biopsies for bladder cancer diagnosis, prognosis and BCG treatment response
• Tracey Edgell, PhD – Hudson Institute of Medical Research, Monash University
  A novel non-hormonal therapeutic path for improving pregnancy success rates
• Pradipta Ghosh, MD – University of California, San Diego
  Boolean Algorithms to Develop Precision Macrophage Reprogramming Therapeutics in IBD: From Math to (Wo)Man
• Emmet Hirsch, MD – NorthShore University HealthSystem
  Surfactant Protein A (SP-A): A novel agent to prevent preterm birth
• Harmeet Malhi, MB, BS – Mayo Clinic
  Hepatocyte-derived extracellular vesicle sphingolipidomics are a diagnostic and prognostic biomarker in nonalcoholic steatohepatitis
• Hiroshi Miyamoto, MD, PhD – University of Rochester
  The role of latrophilins in urothelial tumorigenesis: a novel chemopreventive target for bladder cancer

“We received a record number of applications in response to the 2018-19 Ferring Innovation Grants call for proposals. The quality of the submissions was outstanding, and those selected for funding represent the leading edge of research and innovation in their respective fields,” said Keith James, President Ferring Research Institute, Senior Vice President Research & Development.

About Ferring Research Institute, Inc.

Located in San Diego, California, Ferring Research Institute, Inc. (FRI) is a global therapeutics research center for Ferring Pharmaceuticals. FRI is committed to delivering a pipeline of innovative therapies which improve the lives of patients in the areas of reproductive medicine and women’s health, urology, gastroenterology and hepatology. For more detailed information please visit www.ferring-research.com.

About Ferring Pharmaceuticals

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women’s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

Learn more at www.ferring.com, or connect with us on Twitter, Facebook, Instagram, LinkedIn and YouTube.

For more information, please contact

Bhavin Vaid
Head of Corporate Communications
+41 58 301 09 52 (direct)
+41 79 191 06 32 (mobile)
bhavin.vaid@ferring.com 

Lindsey Rodger
Senior Manager, Corporate Communications
+41 58 451 40 23 (direct)
+41 79 191 04 86 (mobile)
lindsey.rodger@ferring.com

Ferring Pharmaceuticals and Evotec AG form strategic research alliance in reproductive medicine and women’s health

• Ferring will access Evotec’s integrated small molecule discovery and development platform to progress new molecules from concept to potential drug candidates.

• Evotec will apply its drug discovery platform to design novel and efficacious treatments.

• Collaboration demonstrates Ferring’s commitment to working with industry leaders such as Evotec to advance reproductive medicine and women’s health.

Saint-Prex, Switzerland & Hamburg, Germany – 17 October, 2018 –

Ferring Pharmaceuticals and Evotec AG (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) today announced a strategic research alliance to discover and develop new small molecule therapies to treat patients living with fertility and gynaecological conditions.

Evotec will apply its drug discovery platform to design novel and efficacious treatments in partnership with Ferring. The multi-target, multi-year collaboration aims to deliver small molecule pre-clinical development (PDC) and investigational new drug (IND) ready candidates. As part of the alliance, Evotec is eligible for undisclosed research funding and milestones.

“To achieve leadership in reproductive medicine and women’s health, we are expanding beyond our historical expertise in peptides and tackling molecular targets that are best addressed using small molecule therapeutics,” said Per Falk, Chief Science Officer, Ferring Pharmaceuticals. “Evotec is a highly regarded company in this field, and this alliance offers the prospect of significant innovation for patients. Together, we have the potential to make a difference for both men and women who are struggling to start a family, and for women suffering from gynaecological conditions.”

“The integration of our industry-leading small molecule discovery and development platform with Ferring’s expertise in reproductive medicine and women’s health will create a powerful combination that we hope will create a difference for patients suffering from fertility and gynaecological conditions. We very much look forward to working with such an innovative partner,” commented Dr Mario Polywka, Chief Operating Officer of Evotec.

About Ferring Pharmaceuticals

Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women’s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years. Today, over one third of the company’s research and development investment goes towards finding innovative and personalised healthcare solutions to help mothers and babies, from conception to birth. Founded in 1950, Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.

Learn more at www.ferring.com, or connect with us on Twitter, Facebook, Instagram, LinkedIn and YouTube.

About Evotec AG

Evotec is a drug discovery alliance and development partnership company focused on rapidly progressing innovative product approaches with leading pharmaceutical and biotechnology companies, academics, patient advocacy groups and venture capitalists. We operate worldwide and our more than 2,400 employees provide the highest quality stand-alone and integrated drug discovery and development solutions. We cover all activities from target-to-clinic to meet the industry’s need for innovation and efficiency in drug discovery and development (EVT Execute). The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuronal diseases, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases and fibrosis. On this basis, Evotec has built a broad and deep pipeline of approx. 100 co-owned product opportunities at clinical, pre-clinical and discovery stages (EVT Innovate). Evotec has established multiple long-term alliances with partners including Bayer, Boehringer Ingelheim, Celgene, CHDI, Novartis, Novo Nordisk, Pfizer, Sanofi, Takeda, UCB and others.

For additional information please go to www.evotec.com and follow us on Twitter @EvotecAG

Forward looking statements

Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.

For more information, please contact

Bhavin Vaid
Head of Corporate Communications
+41 58 301 09 52 (direct)
+41 79 191 06 32 (mobile)
bhavin.vaid@ferring.com

Lindsey Rodger
Senior Manager, Corporate Communications
+41 58 451 40 23 (direct)
+41 79 191 04 86 (mobile)
lindsey.rodger@ferring.com

Gabriele Hansen
VP Corporate Communications & Investor Relations
T. +49 (0)40 560 81 255
F. +49 (0)40 560 81 333
gabriele.hansen@evotec.com